What a classic example

Posted: March 4, 2012 in Breast Cancer
Tags: , , ,

Today, I am merely posting an article that was published less than a month ago. Folks, radiation is no joke. Not in therapy, not in hospitals, not in dentists’ offices, not in airports. Doctors prescribe it willy nilly like it’s not harmful. Like radiation toxicity isn’t deadly, first of all.

I had radiation treatment to both sides of my chest back in the day. Twelve weeks of radiation, five days a week. And before that, I had had a stem cell transplant, so my stem cells were squeaky clean. Then I had radiation. Then that cancer got mean enough to take over my abdomen and skeleton.

I’ve told people for years that radiation is no laughing matter. It totally obliterated my pectoral muscles and it took years to do it. It’s the gift that keeps on giving long after you’re done. It changes your DNA and there’s no repairing it. Most people scoffed at me. Well, you scoffers … And you know who you are … Open your eyes, engage your brain, and quit taking everyone else’s word for it! And then stop getting those bloody mammograms because they’re radiation plus trauma. I have said for years that mammos exacerbate breast cancer.

And how typical. Just look at how, now that they have proven what radiation does, they try to find a way to still keep the radiation. Its the freakin radiation that’s the problem! How can people who are so educated be so ignorant? Oh wait … It’s all about the money, money, money … At our expense, both financially and physically. Sweet jumping Jehoshaphat.

“Monday, February 13, 2012

Radiation Treatment Transforms Breast Cancer Cells Into Cancer Stem Cells

Breast cancer stem cells are thought to be the sole source of tumor
recurrence and are known to be resistant to radiation therapy and don’t
respond well to chemotherapy.

Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s
Jonsson Comprehensive Cancer Center report for the first time that radiation
treatment -despite killing half of all tumor cells during every treatment –
transforms other cancer cells into treatment-resistant breast cancer stem
cells.

The generation of these breast cancer stem cells counteracts the otherwise
highly efficient radiation treatment. If scientists can uncover the
mechanisms and prevent this transformation from occurring, radiation
treatment for breast cancer could become even more effective, said study
senior author Dr. Frank Pajonk, an associate professor of radiation oncology
and Jonsson Cancer Center researcher.

“We found that these induced breast cancer stem cells (iBCSC) were generated
by radiation-induced activation of the same cellular pathways used to
reprogram normal cells into induced pluripotent stem cells (iPS) in
regenerative medicine,” said Pajonk, who also is a scientist with the Eli
and Edythe Broad Center of Regenerative Medicine at UCLA. “It was remarkable
that these breast cancers used the same reprogramming pathways to fight back
against the radiation treatment.”

The study appears DATE in the early online edition of the peer-reviewed
journal Stem Cells.

“Controlling the radiation resistance of breast cancer stem cells and the
generation of new iBCSC during radiation treatment may ultimately improve
curability and may allow for de-escalation of the total radiation doses
currently given to breast cancer patients, thereby reducing acute and
long-term adverse effects,” the study states.

There are very few breast cancer stem cells in a larger pool of breast
cancer cells. In this study, Pajonk and his team eliminated the smaller pool
of breast cancer stem cells and then irradiated the remaining breast cancer
cells and placed them into mice.

Using a unique imaging system Pajonk and his team developed to visualize
cancer stem cells, the researchers were able to observe their initial
generation into iBCSC in response to the radiation treatment. The newly
generated iBCSC were remarkably similar to breast cancer stem cells found in
tumors that had not been irradiated, Pajonk said.

The team also found that the iBCSC had a more than 30-fold increased ability
to form tumors compared to the non-irradiated breast cancer cells from which
they originated.

Pajonk said that the study unites the competing models of clonal evolution
and the hierarchical organization of breast cancers, as it suggests that
undisturbed, growing tumors maintain a small number of cancer stem cells.
However, if challenged by various stressors that threaten their numbers,
including ionizing radiation, the breast cancer cells generate iBCSC that
may, together with the surviving cancer stem cells, repopulate the tumor.

“What is really exciting about this study is that it gives us a much more
complex understanding of the interaction of radiation with cancer cells that
goes far beyond DNA damage and cell killing,” Pajonk said. “The study may
carry enormous potential to make radiation even better.”

Pajonk stressed that breast cancer patients should not be alarmed by the
study findings and should continue to undergo radiation if recommended by
their oncologists.

“Radiation is an extremely powerful tool in the fight against breast
cancer,” he said. “If we can uncover the mechanism driving this
transformation, we may be able to stop it and make the therapy even more
powerful.”

This study was funded by the National Cancer Institute, the California
Breast Cancer Research Program and the Department of Defense. UCLA’s Jonsson
Comprehensive Cancer Center has more than 240 researchers and clinicians
engaged in disease research, prevention, detection, control, treatment and
education. One of the nation’s largest comprehensive cancer centers, the
Jonsson center is dedicated to promoting research and translating basic
science into leading-edge clinical studies. In July 2011, the Jonsson Cancer
Center was named among the top 10 cancer centers nationwide by U.S. News &
World Report, a ranking it has held for 11 of the last 12 years. For more
information on the Jonsson Cancer Center, visit our website at
http://www.cancer.ucla.edu .

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Comments
  1. Jeanne Allen says:

    Yes, I finnaly listened to you! I have not had a mamogram for several years now!!! I still once in a while get a call from my insurance company saying that I am due for a mamo and I just ignore it!!!! I do not know if you have read it, but I found a book by Suzanne Somers called “Knockout”. I am about a third of the way through it and it is an eye opener!!! But you did tell me about some of it already! Jeanne, Gypsy and Jester

  2. hollykins says:

    RE: the UCLA study re: radiation induced stem cells are alarming. I am strongly considering having mastectomy now that I know what I know (had lumpectomy/brachytherapy 2011). I wonder if anyone else has thought to take similar action?

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